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T-cell (TCR) leukemia & lymphoma

contains CCAP BACs that span the known breakpoint regions
 Many sub-types of T-cell leukemias are associated with chromosomal translocations involving the T-cell receptor genes (TCRA, TCRB, TCRD and TCRG). Because of the somatic rearrangement of the TCR genes that occurs normally, these genes can accidentally associate with a proto- oncogene in a chromosomal translocation, thus activating it, resulting in a T-cell neoplasia. Below is a table of genes involved in these translocations. This disease specific set contains CCAP BACs that span the known breakpoint regions in order to detect disruption of the normal sequence using FISH.
Shipping Information:
Clones are provided as a live culture in a 2ml tube. Each tube contains LB medium supplemented with 8% glycerol and the appropriate antibiotic. we will ship your order at room temperature via express delivery. Store the clones at -80°C.

 

CCAP Disease Specific Sets - T-cell receptor genes
 
Genes
 
Band
TAL1
 
1p33
BCL10
 
1p22.3
LCK 1p35.1
TCRB
 
7q34
TCRG (TRG)
 
7p15-p14
MYC
 
8q24.21
PVT1
 
8q24
ABL
 
9q34.12
HOX11 (TLX1)
 
10q24.31
LMO2
 
11p13
LMO1
 
11p15.4
TCRD (TCRD) and TCRA
 
14q11.2
TRDD3 14q11
 TCL1 (TCL1A)  14q32.13
 IGH  14q32.33
 BHLHB1 (RACK17, PRKCBP2, OLIG2)  21q22.11

 

Purchasing Information
Catalog No.
Description
Literature
BHS1028
BAC: MHB Path collection - T-cell Leukemia & Lymphoma
 

 

 

 

 

 

For more information :: Bioxys and Gentaur BVBA :: Av. de l'Armée 68 B4 :: BE-1040 BELGIUM

Email: info@gentaur.com
 

International 

+32 (0) 16 58 90 45

+32 (0) 16 50 90 45

France

01 43 25 01 50

01 43 25 01 60

Italy

02 36 00 65 93

02 36 00 65 94

Germany

0241 6085 13140

0241 6085 33033

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Last modified: feb-07