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shRNAmir librariesincreased and specific knockdown
The Expression Arrest™ microRNA-adapted
shRNA (shRNAmir) libraries were developed in collaboration with Greg
Hannon (CSHL) and Steve Elledge (Harvard). shRNAmir triggers for
mammalian RNAi are based on current knowledge of the endogenous
microRNA biogenesis pathway. shRNAmir constructs are designed to mimic a
natural microRNA primary transcript, enabling specific processing by the
endogenous RNAi pathway and producing more effective knockdown. In
addition each gene-specific shRNAmir sequence has been selected based on
thermodynamic criteria for optimal small RNA performance (Silva et al
2005).
shRNAmir libraries incorporate several features aimed at increasing the efficiency and specificity of gene knockdown providing solutions for diverse RNAi applications. These include:
shRNAmir libraries targeting the human and
mouse whole genomes are available as:
pSM2 Retroviral shRNAmir pGIPZ Lentiviral shRNAmir Individual shRNAmir constructs, RNAintro starter kits, gene families/pathways, custom rearrays and whole genome libraries are available. Finding your shRNAmir of interest
Enter gene symbol(s) or GenBank accession
number(s) into the clone query or into the shRNA query (
 )
in the purchase grid. Results highlighted by a yellow icon are exact
matches to your search criteria. Click on the details link for
additional information including hairpin sequences. Order directly
online. Constructs are shipped in 48 hours. Alternatively you can send
your gene symbols or accession numbers to us at
info@gentaur.com and our technical
representatives will perform your search for you.
This product is covered by a
Limited Use License
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