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This
Package Insert is provided for product evaluation purposes only and
is
not intended to be used in place of the Package Insert shipped with
the product.
OXI-TEK
NUCLEOSIDE STANDARD
8-Oxo-dG
The development
of this product was supported in part by
grants from the National Cancer Institute (R42 CA80451)
and the New York Center for Biotechnology.
FOR RESEARCH USE ONLY.
NOT FOR in vitro DIAGNOSTIC OR CLINICAL USE
8-Oxo-2'
Deoxy Guanosine (8-Oxo-dG)
(8-Oxo-dG): 8-Oxo-7,8
dihydro-2'-deoxyguanosine ( Also known as 8-hydroxy- 2'
-deoxyguanosine; 8-oxo-2-deoxyguanosine)
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PRODUCT
CHARACTERISTICS |
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(8-Oxo-dG)serves
as a marker of oxidative DNA damage in biological systems.(1)
(8-Oxo-dG) has been chemically
synthesized to improve reliability and accuracy and purified
by HPLC. (2) Identification of the product and an
index of its purity was accomplished by proton NMR
spectroscopy at 400 MHz.(3) |
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FORMULA/WEIGHT/
PURITY |
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Mol. F:
C10H13N5O5 FW: 283.24 Purity: >98% |
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RECOMMENDED
USAGE |
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8-Oxo-dG may be
used as an internal standard for quantitation of DNA damage
by various methods including LC-MS. |
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STORAGE
AND STABILITY |
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Supplied at ~1.0
mg/vial. Lyophilized product is stable for 1 year when
stored at 2-8ºC. Recommend aliquoting and storing at -20°C
when resuspended in water. |
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NMR
SPECTRUM |
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REFERENCES |
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- ESCODD
(European Standards Committee on Oxidative DNA Damage)
Free Radical Research
(2000) 32, 333-341.
- A.E.
Maccubbin, H.B. Patrzyc, N. Ersing, Budzinski, J.B.
Dawidzik, J.C. Wallace, H. Iijima, H. C. Box,
Biochimica et Biophysica Acta (1999) 1454, 80-88.
- H.C.
Box, H.G. Freund, E.E. Budzinski, J.C. Wallace and A.E.
Maccubbin,
Radiation Research, (1995) 141, 91-94.
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Rev.: 01/03 |
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Corporation
872 Main Street
Buffalo, New York 14202
Office Phone: 716-882-0920
Fax: 716-882-0959
|
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58 90 45 
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