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Cultrex® 3D Culture Matrix™ BME
| 3-D Culture is an innovative
approach to modeling the morphological effects of early oncogenesis on
glandular epithelial cells. When healthy, these cells exhibit a
structured, polarized morphology that is critical for cellular formation
and function. During carcinoma development, cell cycle controls
associated with cellular development, proliferation and death are lost,
and as a result, these ascinaric structures are disrupted. In effect,
the morphology of these structures can be used as a measure to study
factors in early carcinoma development. Trevigen has developed Cultrex
3-D Culture Matrix BME which is the first Basement Membrane Extract
produced and qualified specifically for use in 3-D culture studies. |
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| The 3-D Culture Matrix
provides the foundation for glandular epithelial cells to grow
in three dimensions allowing for the formation of ascinar
structures in vitro. |
| Reduced Basement Membrane Extract without phenol
red. |
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| Store at -20° C or -80° C in a
manual defrost freezer. Avoid repeated freeze-thaw cycles. |
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| Debnath J, Muthuswamy SK, Brugge
JS: Morphogenesis and oncogenesis of MCF-10A mammary epithelial
acini grown in three-dimensional basement membrane cultures.
Methods, 2003 pp. 256-268. |
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Products
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3445-048-01 |
Cultrex®
3-D Culture Matrix™ BME, 15 ml |
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+32 (0) 16
58 90 45 
+32 (0) 16
50 90 45