Nitric Oxide Synthase Inhibitors

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Catelog Number :

00240

Product Name :

7-Nitroindazole (7-NI)

Description:

7-NI is a selective inhibitor for the brain nitric oxide synthase (NOS). See NOS inhibitor kit 00249

Yellow orange solid soluble in DMSO.
Store at 4°C.
C₇H₅N₃O₂.
Mwt.: 163.1.
[2942-42-9].

Chemical Structure of 00240

Reference:

1) Moore, et al. Methods in Enzymology 268, 393(1995);2) Faraci, et al. Stroke 26(11), 2172(1995); 3) Babbedge, et al. Br. J. Pharmacol. 110(1), 225(1993).

Catelog Number :

00242

Product Name :

L-NIL(N⁶-(1-iminoethyl)-lysine, hydrochloride)

Description:

L-NIL is a potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC₅₀ = 3.3 µM) than for the rat brain constitutive enzyme (IC₅₀ = 92 µM). It exhibits about 10-fold greater inhibitory potency than NG-monomethyl-L-arginine in inhibiting ?-interferon-induced NO₂ - production (IC₅₀ = 460 nM). See NOS inhibitor kit (00249).

White solid soluble in water
Store at -20°C
C₈H₁₈ClN₃O₂
Mwt: 223.7
[150403-89-7]

Chemical Structure of 00242

Reference:

1) Moore, et al. J. Med. Chem. 77, 3886(1994); 2) Stenger, et al. Eur. J. Pharmacol. 294(2-3), 703(1995); 3) Southan, et al. Biochem. Pharmacol. 51(4), 383(1996).

Catelog Number :

00243

Product Name :

L-NIO (N⁵-(1-iminoethyl)-L-ornithine, dihydrochloride)

Description:

L-NIO is a potent, irreversible inhibitor of neutrophil nitric oxide synthase. See NOS inhibitor kit (00249).

White solid soluble in water
Store at -20°C
C₇H₁₇Cl₂N₃O₂.
Mwt: 246.1
[36889-13-1]

Chemical Structure of 00243

Reference:

1) McCall, et al. Br. J. Pharmacol. 102(1), 234(1991); 2) Mulligan, et al. Br. J. Pharmacol. 107(4), 1159(1992).

Catelog Number :

00241

Product Name :

L-NMMA (N^G-methyl-L-arginine, acetate salt)

Description:

L-NMMA competitively inhibits nitric oxide synthase in a wide range of cells. See NOS inhibitor kit (00249).

White solid soluble in water
Store at -20°C
C₉H₂₀N₄O₄
Mwt: 248.3
[53308-83-1]

Chemical Structure of 00241

Reference:

1) Baron, et al. Am. J. Physiol. 269, E709(1995); 2) Oddis, et al. Biochem. Biophys. Res. Comm. 205, 992(1994).

Catelog Number :

00249

Product Name :

NOS Inhibitor Kit

Description:

This kit contains four NOS inhibitors: 7-NI (00240) (50 mg), L-NMMA (00241) (25 mg), L-NIL (00242) (5 mg) and L-NIO (00243) (5 mg).

Reference:

Nitric Oxide Synthase Inhibitors

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Send mail to webmaster with questions or comments about this web site.
Copyright © 2005 Gentaur BVBA
Last modified: feb-07