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Natural Products Specifications
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Catelog Number :
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00010 |
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Product Name :
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a-Bungarotoxin
(from Bungarus multicinctus) |
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Description:
A potent inhibitor for the motor endplate acetylcholine
receptor (Kd = 1 nM to 1 pM). Also see our fluorescently
labeled and biotin labeled a-bungarotoxins.
- White solid soluble in water.
- Store at -20°C and protect from light.
- C338H529N97O105S11.
- Mwt: 7984.
- [11032-79-4].
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Reference:
Zhang , et al. Neuron, 12, 167(1994). |
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Catelog Number :
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00011 |
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Product Name :
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Fluorescein-a-bungarotoxin |
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Description:
Fluorescein- a-bungarotoxin binds
to the nicotinic acetylcholine receptor with high affinity,
and thus can be used to image the distribution of the
receptor at the neuromuscular junctions. Also see our other
dye- and biotin-labeled a-
bungarotoxins.
-
 ex\em
= 494nm\518 nm.
- Soluble in water.
- Store at -20°C and protect from light, especially
when in solution.
- Mwt: ~ 8400.
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Reference:
1) Science 196, 540(1977); 2) Muscle &Nerve 5,
140(1982) |
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Catelog Number :
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00012 |
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Product Name :
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Tetramethylrhodamine-a-Bungarotoxin |
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Description:
Tetramethylrhodamine- a-Bungarotoxin
binds to the nicotinic acetylcholine receptor with high
affinity, and thus can be used to image the distribution of
the receptor at the neuromuscular junctions. Also see other
labeled a- bungarotoxin
products.
-
ex\em=
553nm\577nm.
- Soluble in water.
- Store at -20°C and protect from light, especially
when in solution.
- Mwt: ~8400.
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Reference:
Anderson, et al. J. Cell Biol. 99, 1769(1984) |
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Catelog Number :
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00013 |
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Product Name :
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Fluorescein-a-bungarotoxin |
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Description:
See 00011 for product description. |
Reference: |
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Catelog Number :
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00014 |
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Product Name :
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Tetramethylrhodamine-a-Bungarotoxin |
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Description:
See 00012 product description. |
Reference: |
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Catelog Number :
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00015 |
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Product Name :
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Sulforhodamine 101-a-bungarotoxin
(also called Texas Red-a-bungarotoxin) |
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Description:
Sulforhodamine 101- a-bungarotoxin
binds to the nicotinic acetylcholine receptor with high
affinity. Since the dye sulforhodamine 101 has a longer
absorption and emission wavelengths ( ex\ em=
593/613 nm) than tetramethylrhodamine- a-bungarotoxin
(# 00012 ), it gives a better spectral
separation when a green fluorescent probe such as
SynaptoGreen C4 (FM1-43, # 70020 ) is
also used in the experiment. Also see other labeled
a- Bungarotoxins.
Soluble in water
Store at -20°C and protect from light, especially in
solution
Mwt: 8600
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Reference:
1) J Cell Biol 150, 1385 (2000); 2) Neuron 23,
675(1999). |
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Catelog Number :
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00016 |
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Product Name :
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Sulforhodamine 101-a-bungarotoxin
(also called Texas Red-a-bungarotoxin) |
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Description:
See 00015 for product description. |
Reference:
J Cell Biol 150, 1385 (2000); 2) Neuron 23,
675(1999).
*Texas Red is a trademark of Molecular Probes, Inc. |
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Catelog Number :
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00017 |
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Product Name :
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Biotin-XX-a-Bungarotoxin |
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Description:
Biotinylated a-bungarotoxin is
useful in the affinity column isolation of the nicotinic
AChR using an avidin or streptavidin agarose. 1
Nicotinic AChRs labeled with biotin-XX- a-bungarotoxin
can be localized using enzymeor fluorophore-labeled
conjugates of avidin or streptavidin. 2,3
- White lyophilized solid soluble in water
- Store at -20°C and protect from light
- Mwt: ~8400
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Reference:
1) J Cell Biol 125, 661-668 (1994); 2) J Biol Chem
268, 25108(1993); 3) Proc Natl Acad Sci U S A 77, 4823(1980) |
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Catelog Number :
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00019 |
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Product Name :
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b-Bungarotoxin
(from Bungarus Multicinctus) |
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Description:
b -Bungarotoxin blocks
neurotransmission at neuromuscular junctions. The toxin
contains a smaller subunit that blocks voltage-gated K +
channels on the presynaptic membranes, and a larger subunit
that has phospholipase A 2 activity.
- Lyophilized white powder soluble in water.
- Store at -20°C and protect from light.
- Mwt: ~ 20,000.
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Reference:
1) J. Biochem. 84, 1301(1978);2) Neuroscience 40,
29(1991) |
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Catelog Number :
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00020 |
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Product Name :
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Biotin-cAMP,
diisopropylethylammonium salt |
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Description:
Biotin-cAMP is a cAMP analog and can be used to probe cAMP
receptors.
- White lyophilized solid soluble in water
- Store at -20°C and protect from light
- C34H55N10O10PS
- Mwt: 826
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Chemical Structure of 00020
Reference: |
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Catelog Number :
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00020-1 |
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Product Name :
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Biotin-cAMP,
diisopropylethylammonium salt |
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Description:
#00020-1 offers a more convenient packaging size for
biotin-cAMP. For detailed molecular information, see
00020. |
Chemical Structure of 00020-1
Reference: |
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Catelog Number :
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00021 |
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Product Name :
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Biotin-cGMP,
diisopropylethylammonium salt |
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Description:
Biotin-cGMP has been used as a tracer in immunoassays for
the cGMP measurement in plasma or urine samples.
- White lyophilized solid soluble in water
- Store at -20°C and protect from light
- C34H55N10O11PS
- Mwt: 832
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Chemical Structure of 00021
Reference:
J. Immunoassay 16(1), 37(1995). |
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Catelog Number :
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00021-1 |
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Product Name :
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Biotin-cGMP,
diisopropylethylammonium salt |
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Description:
See 00021 for product description. |
Chemical Structure of 00021-1
Reference: |
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Catelog Number :
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00022 |
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Product Name :
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Cyanine 644-cAMP |
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Description:
Cyanine 644-cAMP is a fluorescently labeled cAMP analog and
can be used to probe cAMP receptors. Single molecule of
fluorescently labeled cAMP has recently been imaged as the
probe binds to the receptor on the surface of
Dictyostelium cells 1.
-
ex\em(MeOH)
= 644/ 670nm
- Dark solid soluble in MeOH, DMF or DMSO
- Store at -20°C and protect from light
- C50H61N9O12PS.
- Mwt: 1043.11
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Chemical Structure of 00022
Reference:
1) M.Ueda, et al. Science 294, 864(2001) |
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Catelog Number :
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00022-1 |
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Product Name :
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Cyanine 644-cAMP |
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Description:
See 00022 for product description. |
Chemical Structure of 00022-1
Reference:
1) M.Ueda, et al. Science 294, 864(2001) |
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Catelog Number :
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00023 |
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Product Name :
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Fluorescein Methotrexate,
triammonium salt |
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Description:
Fluorescein methotrexate is useful for studying
antimetabolite resistance and spontaneous gene
amplification. The dye is actively taken up by cells and
binds to dihydrofolate reductase (DHFR) quantitatively.
-
ex\em
= 496/516nm
- Yellow solid soluble in pH>6.5 buffer, DMF or DMSO
- Store at -20°C and protect from light
- C46H54N14O9S.
- Mwt:979.08
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Chemical Structure of 00023
Reference:
1) J Cell Biol 162, 23 (2003); 2) Nat Biotechnol 19,
769-772 (2001); 3) J. Bol. Chem. 257, 14162(1982) |
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Catelog Number :
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00024 |
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Product Name :
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Phallacidin |
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Description:
Phallacidin and phalloidin are two of the phallotoxins
isolated from the poisonous mushroom Amanita phalloides.
Both toxins stain F-actin at nanomolar affinity and can be
used interchangeably. The unlabeled toxins can be used as
controls for staining experiments using the labeled toxins.
- White solid soluble in MeOH
- Store at -20°C and protect from light
- C37H50N8O13S
- Mwt: 846.9
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Chemical Structure of 00024
Reference:
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Catelog Number :
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00025 |
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Product Name :
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Staurosporine |
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Description:
Staurosporine is a potent and cell-permeable inhibitor of a
wide variety of protein kinases, 1,2 including
protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7
nM), and protein kinase G (IC50 = 8.5 nM). Staurosporine
induces apoptosis in human neuroblastoma cells and chick
embryonic neurons. 3,4
- Soluble in DMSO or ethanol
- Store at -20°C and protect from light, especially in
solution
- C28H26N4O3
- Mwt: 466.20
- [62996-74-1]
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Chemical Structure of 00025
Reference:
1) Biochem. Biophys. Res. Commun. 158, 105(1989); 2)
Biochem. Biophys. Res. Commun. 135, 397(1986); 3) Neuropharmacology 36,
811(1997); 4) J. Neurochem. 66, 1418(1996). |
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Catelog Number :
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00026 |
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Product Name :
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Rhodamine 110-TaxolTM |
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Description:
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Rhodamine 110 Taxol can be used to stain microtubules.
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Reference: |
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Catelog Number :
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00027 |
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Product Name :
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Rhodamine phalloidin |
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Description:
Rhodamine phalloidin is the most widely used F-actin stain. 1-3
The red fluorescent probe binds to F-actin with nanomolar
affinity and is highly photostable. The fluorescent
phallotoxins are typically applied to fixed and
permeabilized cells but can also be loaded into live cells
via cationic liposomes. 4 Each vial contains
sufficient probe for staining ~300 microscope slide
preparations (300 U).
-
abs\em(MeOH)
= 542/ 565nm
- Red solid soluble in MeOH.
- Store at -20°C and protect from light
- C60H70N12O13S2
- Mwt: 1231
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Chemical Structure of 00027
Reference:
1) J Biol Chem 273, 11144(1998); 2) Biochemistry 34,
11017(1995); 3) J Cell Biol 129, 179(1995); 4) Neurosci. Lett. 207, 17
(1996). |
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Catelog Number :
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00028 |
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Product Name :
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Biotin-XX Phalloidin |
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Description:
Biotin-XX phalloidin stains F-actin with nanomolar affinity.
The long flexible spacer group XX facilitates interaction
between biotin and avidin or streptavidin which can be
labeled with a fluorophore or an enzyme for visualization of
F-actin. Biotin-XX phalloidin can also be used for detecting
F-actin by electron microscopy. The content in each vial is
sufficient for ~100 microscope slide preparation (100 U).
- White lyophilized solid soluble in methanol
- Store at -20°C and protect from light
- C57H85N13O14S2
- Mwt: 1240
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Chemical Structure of 00028
Reference:
1) J. Cell Biol. 130, 591(1995). |
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Catelog Number :
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00029 |
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Product Name :
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Rhodamine 110 Phallacidin |
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Description:
Similar to fluorescently labeled phalloidins, rhodamine 110
phallacidin binds to F-actin with nanomolar affinity. The
green fluorescent rhodamine 110 phallacidin has exceptional
photostability and is a superior substitute for fluorescein
phalloidin or Alexa TM 488 dye-labeled phalloidin
or phallacidin. The fluorescent phallotoxins are typically
applied to fixed and permeabilized cells but can also be
loaded into live cells via cationic liposomes.
-
ex\em(MeOH)
= 542/ 565nm
- Red solid soluble in MeOH.
- Store at -20?C and protect from light
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Chemical Structure of 00029
Reference: |
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Catelog Number :
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00030 |
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Product Name :
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Fluorescein phalloidin |
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Description:
Fluorescein phalloidin stains F-actin with nanomolar
affinity. The fluorescent probe is typically applied to
fixed and permeabilized cells. 1-3 Fluorescent
phallotoxins can also be loaded into live cells via cationic
liposomes. 4 The green fluorescent fluorescein
phalloidin was one of the earlier fluorescent phallotoxins
developed and is still widely used for visualizing F-actin
(Also see rhodamine 110 phallacidin for superior
photostability,
00029). Each vial contains sufficient probe for staining
~300 microscope slide preparations (300 U).
-
abs\em
(Ph8) = 496/ 516nm
- Yellow solid soluble in MeOH.
- Store at -20°C and protect from light
- C56H60N10O15S2
- Mwt: 1177
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Chemical Structure of 00030
Reference:
1) J Biol Chem 273, 11144(1998); 2) Biochemistry 34,
11017(1995); 3) J Cell Biol 129, 179(1995); 4) Neurosci. Lett. 207, 17
(1996). |
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Catelog Number :
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00031 |
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Product Name :
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Phalloidin |
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Description:
Phallacidin and phalloidin are two of the phallotoxins
isolated from the poisonous mushroom Amanita phalloides.
Both toxins stain F-actin at nanomolar affinity and can be
used interchangeably. The unlabeled toxins can be used as
controls for staining experiments using the labeled toxins.
- White solid soluble in MeOH
- Store at -20°C and protect from light
- C35H48N8O11S
- Mwt: 788.87
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Chemical Structure of 00031
Reference: |
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Catelog Number :
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00060 |
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Product Name :
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Tetrodotoxin, citrate free |
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Description:
Tetrodotoxin (TTX) reversibly blocks the excitable sodium
channels and has been a widely used tool for the studies of
excitable membranes of nerve, skeletal and cardiac cells.
Biotium offers a very high quality TTX with a very
competitive price. Please also see our TTX with citrate ( 00061).
- White solid soluble in slightly acidic ( pH 4.8 )
buffer.
- Store at -20?C.
- C11H17N3O8.
- Mwt: 319.3.
- [4368-28-9].
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Chemical Structure of 00060
Reference:
1) Lysko, P.G. et al. Stroke 25, 2476(1994); 2) Hu,
S.L. and Kao, C.Y. Toxicon 23, 723(1985); 3) Nakamura, M. and Yasumoto,
T. Toxicon 23, 271(1985). |
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Catelog Number :
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00061 |
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Product Name :
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Tetrodotoxin, with
citrate (purity: >98%) |
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Description:
Tetrodotoxin (TTX) reversibly blocks the excitable sodium
channels and has been a widely used tool for the studies of
excitable membranes of nerve, skeletal and cardiac cells.
Biotium offers a very high quality TTX with a very
competitive price. TTX with citrate is a lyophilized mixture
of 1 mg high purity TTX and 5 mg pH 4.8 citrate
buffer.Please also see TTX, citrate-free (# 00060).
- White solid soluble in slightly acidic (pH 4.8)
buffer
- Store at 4°C
- C11H17N3O8
- Mwt: 319.3
- [4368-28-9]
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Reference:
1) Lysko, P.G. et al. Stroke 25, 2476(1994); 2) Hu,
S.L. and Kao, C.Y. Toxicon 23, 723(1985); 3) Nakamura, M. and Yasumoto,
T. Toxicon 23, 271(1985). |
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Catelog Number :
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00062 |
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Product Name :
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Tetrodotoxin, with
citrate (purity: >98% |
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Description:
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See #00061 for product description.
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Reference: |
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Catelog Number :
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29000 |
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Product Name :
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Streptavidin,
R-phycoerythrin conjugate, 1mg/mL (R-phycoerythrin streptavidin
conjugate) |
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Description:
R-phycoerythrin streptavidin conjugate (R-PE streptavidin)
can be used to detect biotinylated molecules with extremely
high sensitivity. The red fluorescent protein
R-phycoerythrin (R-PE) belongs to the family of
phycobiliproteins, which are derived from cyanobacteria and
eukaryotic algae. R-PE has absorption maxima at 496, 546,
and 565 nm respectively and emission at 578 nm. Because of
the high extinction coefficient (~1,960,000) and high
fluorescence quantum yield (~0.82), R-PE is by far the
brightest dye for the 565 nm wavelength region.
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ex\em=
496, 546, 565/578 nm
- Red solution
- Store at -20°C and protect from light
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Reference:
1) Biotechniques 31, 490(2001); 2) Proc. Natl. Acad.
Sci. USA 98, 8862(2001); 3) Proc. Natl. Acad. Sci. USA 97, 2680(2000);
4) Proc. Natl. Acad. Sci. USA 97, 3260(2000); 5) Proc. Natl. Acad. Sci.
USA 95, 3752(1998). |
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Catelog Number :
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29001 |
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Product Name :
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Annexin V, FITC
conjugate (FITC Annexin V) |
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Description:
The green fluorescent FITC annexin V can be used to detect
apoptotic cells. The human anticoagulant annexin V is a 35-
36 kilodalton, Ca 2+-dependent
phospholipid-binding protein with high affinity for
phosphatidylserine (PS). In normal viable cells, PS is
located on the inner leaflet of the cytoplasmic membrane. In
apoptotic cells, however, PS is translocated from the inner
to the outer leaflet of the plasma membrane, where it can be
detected by a fluorescently labeled annexin V.
-
ex\em(pH7)
= 494/ 518 nm
- Yellow solution
- Store at -20°C and protect from light
|
Reference:
1) J. Immunol. Methods 184, 39(1995); 2) Blood 84,
1415 (1994); 3) Cytometry 43, 134 (2001); 4) FEBS Lett. 203, 99 (1986);
5) Biosci. Rep. 7, 289 (1987). |
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Catelog Number :
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29002 |
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Product Name :
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Annexin V, Sulforhodamine
101 conjugate (Texas-Red Annexin V) |
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Description:
The red fluorescent sulforhodamine 101 annexin V (Texas-Red
Annexin V) can be used to detect apoptotic cells. The human
anticoagulant annexin V is a 35- 36 kilodalton, Ca 2+-dependent
phospholipid-binding protein with high affinity for
phosphatidylserine (PS). In normal viable cells, PS is
located on the inner leaflet of the cytoplasmic membrane. In
apoptotic cells, however, PS is translocated from the inner
to the outer leaflet of the plasma membrane, where it can be
detected by a fluorescently labeled annexin V.
-
ex\em(pH7)
= 586/605 nm
- Red solution
- Store at -20?C and protect from light
|
Reference:
1) J. Immunol. Methods 184, 39(1995); 2) Blood 84,
1415 (1994); 3) Cytometry 43, 134 (2001); 4) FEBS Lett. 203, 99 (1986);
5) Biosci. Rep. 7, 289 (1987). |
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Catelog Number :
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40037 |
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Product Name :
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7-AAD
(7-aminoactinomycin D) |
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Description:
7-AAD is a fluorescent DNA intercalator, which upon binding
to dsDNA can be excited by the argon-ion laser and emits at
647 nm. 1-3 7-AAD binds selectively to GC regions
of DNA, which makes the dye useful for chromosome banding
studies. 4
-
ex\em(DNA)
= 546/647 nm
- Orange red solid soluble in DMF or DMSO
- Store at -20°C and protect from light, especially in
solution
- C62H87N13O16
- Mwt: 1270.45
|
Chemical Structure of 40037
Reference:
1) Exp. Parasitol. 97, 141 (2001); 2) Br.
J. Haematol. 104, 530(1990); 3) Cytometry 12, 221(1991); 4)
Chromosoma 68, 287(1978). |
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Catelog Number :
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40038 |
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Product Name :
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Actinomycin D |
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Description:
Actinomycin D is a nonfluorescent GC-selective intercalator. 1
Similar to 7-AAD, actinomycin D has also been used for
chromosome banding studies. 2
ex\em=
442nm/none
Orange red solid soluble in DMF or DMSO
Store at -20°C and protect from light, especially in
solution
C62H86N12O16
Mwt: 1255.43
|
Chemical Structure of 40038
Reference:
1) J. Mol. Biol. 225, 445(1992); 2) Cancer
Genet. Cytogenet. 1, 187(1980). |
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Catelog Number :
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59001 |
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Product Name :
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A-23187 Free Acid
(calcimycin; or Calcium Ionophore III) |
|
Description:
A-23187 is a calcium ionophore that rapidly equilibrates
intracellular and extracellular calcium concentrations. It
is commonly used for in situ calibrations of
fluorescent calcium indicators. The ionophore allows Mn 2+
to enter the cells and quench intracellular fluorescence of
calcium indicators.
- White solid soluble in DMSO.
- Store at 4°C and protect from light.
- C29H37N3O6.
- Mwt: 523.6.
- [52665-69-7].
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Chemical Structure of 59001
Reference:
Suzuki, K. et al. Anal. Chem. 61, 382 (1989);
Caron-Leslie, L.A., et al. FASEB J. 8, 639 (1994);
Merck Index 12, 1678;
Saunders, M.J., et al. Science 217, 943 (19
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Catelog Number :
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59006 |
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Product Name :
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4-Bromo A-23187, free acid |
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Description:
Similar to A-23187, 4-Bromo A-23187 is used for in situ
calibrations of fluorescent Ca 2+ indicators to
equilibrate intracellular and extracellular calcium
concentrations and to allow Mn 2+ to enter cells
to quench indicator fluorescence. However, since 4-bromo
A-23187 is nonfluorescent, it is preferred over the blue
fluorescent A-23187 for calibrations of UV-excited Ca 2+
indicators such as Indo-1 and Fura-2 in order to keep
background fluorescence to a minimum.
- White solid soluble in DMSO or EtOH
- Store at 4°C and protect from light
- C29H36BrN3O6
- Mwt: 602.52
- [76455-48-6]
|
Reference:
1) Anal. Chem. 146, 349 (1985). |
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Catelog Number :
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59007 |
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Product Name :
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Ionomycin,calcium salt |
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Description:
Ionomycin is commonly used to modify intracellular calcium
concentrations and to calibrate fluorescent calcium
indicators. It is also known for its antipoliferative
effects.
- Yellowish oily solid soluble in DMSO or EtOH
- Store desiccated at -20°C
- C41H70O9Ca
- Mwt: 747.1
- [56092-82-1]
|
Reference:
1) J. Biol. Chem. 275, 7071(2000); 2) J. Immunol.
155, 3297 (1995) J. Urol. 162, 916 (1999). |
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Catelog Number :
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70052 |
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Product Name :
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LumitiumTM C9 |
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Description:
Lumitium C9 is a cationic ruthenium complex with two C9
hydrocarbon tails. Ruthenium complexes similar to Lumitium
C9 are known for having a large Stokes shift (>100 nm) and
long luminescence lifetime. Although the utility of the dye
has not been fully tested, it can potentially be used as a
membrane probe offering high sensitivity via time-resolved
detection.
- Orange solid soluble in water
- Store at -20°C and protect from light
- C58H78Cl2N6Ru
- Mwt: 1031.26
|
Chemical Structure of 70052
Reference: |
|
+32 (0) 16
58 90 45 
+32 (0) 16
50 90 45