Product Details: Human recombinant MIP-1 alpha
Basic Information
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| Product ID: |
MI-290-3 |
| Product Name: |
Human recombinant MIP-1 alpha |
| Unit: |
10µg |
| Category: |
Growth Factors, Cytokines, Receptors
and their Antibodies |
| Subcategory: |
Macrophage Inflammatory Proteins |
Product Details
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| Description: |
Macrophage Inflammatory Protein-1(
(MIP-1& alpha) is part of the CC subfamily of the
chemokine superfamily of chemoattractant cytokines.
MIP-1& alpha affects the inflammatory response of blood
monocytes, tissue macrophages, and T cells. MIP-1& alpha
also enhances the formation of granulocyte-macrophage
colonies stimulated by GM-CSF or M-CSF. Human MIP-1&
alpha is composed of 69 amino acid residues with not
possible N-linked glycosylation sites, and several
possible O-linked sites. Human MIP-1& alpha is 60%
homologous with human MIP-1& alpha, 75% homologous with
murine MIP-1& alpha, and has been shown to be active on
murine cells.
Human recombinant MIP-1& alpha is produced in
genetically engineered yeast, and purified by sequential
chromatography.
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| Molecular Weight: |
8 KDa |
| Biological Activity: |
The biological activity of recombinant
human MIP-1&# alpha is determined by its use as a
cofactor for CSF-dependent myelopoiesis.
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| Formulation: |
In water at a concentration of 1.0 mg
protein/ml |
| Purity: |
Over 95% pure by SDS gel
electrophoresis, with low level of endotoxin. |
| Storage Conditions: |
Store at -80°C. |
| Stability: |
Several months at -80°C. |
| Temperature: |
-80°C |
| References: |
1Nathan, C.F. (1987)J. Clin. Invest.
79:319
2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA)
86:612
3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911
2. Dunlop, et al (1992) Blood 79: 2221
3. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895 |
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+32 (0) 16
58 90 45 
+32 (0) 16
50 90 45