Product Details: Human transforming growth factor beta-1
(TGF beta-1) recombinant
Basic Information
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| Product ID: |
GF-230-2 |
| Product Name: |
Human transforming growth factor beta-1
(TGF beta-1) recombinant |
| Unit: |
5µg |
| Category: |
Growth Factors, Cytokines, Receptors
and their Antibodies |
| Subcategory: |
Growth Factors/Cytokines/Enzymes |
Product Details
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| Description: |
Human Transforming Growth Factor beta1
(TGF- beta1 ) is stimulatory for cells of mesenchymal
origin and inhibitory for cells of epithelial or
neuroectodermal origin. Mature TGF- beta1 is a
disulfide-linked homodimer of two chains composed of 112
amino acid residues each. There is a 70% homology
between human TGF- beta1 and human TGF- beta2.
Human TGF- beta1 is produced in genetically
engineered bacteria, and purified by sequential
chromatography.
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| Molecular Weight: |
25 KDa (dimeric protein) |
| Biological Activity: |
The biological activity of human TGF-&#
beta1 is determined by measuring the acidification of
the culture medium (Rat-1 cells) exposed to the growth
factor.
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| Formulation: |
25 µl (0.20 mg/ml) in 5 mM HCl (pH
2.5). Some of the liquid in the vial could have been
evaporated with changes in the final volume. However,
the 5µg of the protein are still inside the vial. We
recommend, in order to control the proper concentration,
to dilute the entire content to a known volume with 5mM
HCl. Do not freeze this material. |
| Purity: |
Over 98% pure by non-reduced SDS gel
electrophoresis. |
| Storage Conditions: |
Store at +4°C. |
| Stability: |
Several months at +4°C. |
| Temperature: |
+4°C |
| References: |
1. Ichijo, H. et al.(1994) The Journal
of Biological Chemistry, Vol 266, No. 33, May,
22459-22464
2. Yan, Z., Winawer, S., and Friedman, E., (1994) The
Journal of Biological Chemistry, Vol 269, No. 18, May,
13231-13237. |
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