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Mouse Monoclonal IgG
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Catalog #: G052 |
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Quantity: 100μg |
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Clone: SRY.G12 |
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Immunogen: SRY-GST fusion
protein. |
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Specificity: Recognize mouse
SRY protein, others not tested. |
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Formulation: 1mg/ml in PBS, pH
7.4 with 0.05% sodium azide. Frozen liquid. |
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Storage/Stability: Stable for 1
year at -20°C from date of shipment. For maximum recovery of
product, centrifuge the original vial after thawing and prior to
removing the cap. Aliquot to avoid repeated freezing and thawing.
Aliquot will be stale at 4°C for 3 months. |
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Application: Western blot
(1:1000) and ELISA (1:2000~5000). The Sex-Determining Region (SRY)
is a gene that encodes a transcription factor that is a member
of the high mobility group HMG-box family of DNA binding
proteins.The gene is located on the short arm of the Y
chromosome and has a gene map locus - Yp11.3.Common synonyms of
the gene name are Testis Determining Factor (TDF) and Testis
Determining Factor on Y (TDY). The main function of the SRY
protein is to initiate male sex determination as a
transcriptional activator, which regulates a genetic switch in
male development. The SRY HMG box recognizes DNA by partial
intercalation in the minor groove. The SRY protein then binds to
the DNA and distorts its shape (SRY protein in action). In doing
so, it regulates genes that control the development of the
testes.
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This product is
distributed for laboratory research only.
Caution: Not for diagnostic use. |
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