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Anti-SCD1 Antibody
| Anti-SCD1 Antibody |
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Mouse Monoclonal IgG2B
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Click to enlarge
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Catalog #: G076 |
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Quantity: 100μg |
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Clone: CD.E10 |
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Immunogen: Full length
recombinant protein.
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Specificity: Reacts with human
and mouse proteins. |
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Formulation: 1mg/ml in PBS, pH
7.4 with 0.05% sodium azide. Frozen liquid. |
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Storage/Stability: Stable for 1
year at -20°C from date of shipment. For maximum recovery of
product, centrifuge the original vial after thawing and prior to
removing the cap. Aliquot to avoid repeated freezing and thawing.
Aliquot will be stale at 4°C for 3 months. |
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Application: Western blot,
ELISA, IP, and IHC in obesity research. Stearoyl-CoA desaturase
(SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is
tightly regulated by signals such as insulin, leptin,
carbohydrate, fatty acids and temperature. The enzyme (mouse
355aa, rat 358aa; ~37 KDa) is constitutively expressed in
adipose tissue and is induced in liver in response to fat free,
high carbohydrate diet. The SCD-1 expression is higher in female
than male mouse. The repression of RNA levels and enzyme
activity of hepatic SCD-1 by Leptin has been shown to
significantly reduce the triglyceride storage, VLDL production
and therefore an increase in fatty acid oxidation. Inhibition of
SCD-1 could be of benefit for treatment of obesity, hepatic
steatosis and other metabolic disorders.
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This product is
distributed for laboratory research only.
Caution: Not for diagnostic use. |
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